CPNE8

Across TCGA patient cohorts, CPNE8 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPNE8-associated genes across cancer lineages are PDCD4, ASNS, and ATM. Each is linked with CPNE8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPNE8-to-partner and partner-to-CPNE8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CPNE8-low versus CPNE8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE8→partner) and Y-score (partner→CPNE8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.527	-2.000	<.001	.029	3	2
UCEC	ASNS →	+0.475	+1.938	<.001	.001	3	2
UCEC	ATM →	-0.450	-3.000	.002	<.001	3	2
UCEC	4E-BP1 →	+0.294	+2.807	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.327	-2.643	<.001	<.001	3	1
UCEC	ERK2 →	+0.169	+1.700	.007	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PDCD4 by CPNE8 expression — UCEC

Explore this box plot interactively →