CPNE2

Across TCGA patient cohorts, CPNE2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPNE2-associated genes across cancer lineages are JNK2, 14-3-3_beta, and eEF2. Each is linked with CPNE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CPNE2-to-partner and partner-to-CPNE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CPNE2-low versus CPNE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE2→partner) and Y-score (partner→CPNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.251	+2.727	<.001	.002	3	3
UCEC	14-3-3_beta →	-0.127	-3.880	<.001	<.001	3	2
COAD	eEF2 →	+0.439	+2.841	<.001	.033	3	2
COAD	EGFR_pY1068 →	-0.437	-3.169	.003	.017	3	2
UCEC	A-Raf_pS299 →	-0.120	-1.247	.003	.045	3	2
COAD	ERK2 →	+0.261	+3.000	.002	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

JNK2 by CPNE2 expression — UCEC

Explore this box plot interactively →