CPNE2

Across TCGA cell cohorts, CPNE2 mutation is significantly associated with the RNA expression of many other genes, with 322 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPNE2-associated genes across cancer lineages are C4orf50, GUCA1C, and UGT2B17. Each is linked with CPNE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPNE2-to-partner and partner-to-CPNE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf50 grouped by CPNE2-low versus CPNE2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE2→partner) and Y-score (partner→CPNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	2
LIVER	GUCA1C →	+0.038	+3.459	<.001	.004	3	1
LIVER	UGT2B17 →	+0.018	+3.459	.007	.004	3	1
LARGE_INTESTINE	C12orf57 →	+0.897	+3.212	.002	.006	3	1
LARGE_INTESTINE	RPS12 →	+0.621	+3.212	<.001	.006	3	1
LARGE_INTESTINE	TXNDC15 →	+0.658	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 322 associations by consensus.

C4orf50 by CPNE2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →