Across TCGA pan-cancer cohorts, CPNE1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CPNE1 data layer compared with 20 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CPNE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CPNE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

MESO, UCEC, and HNSC are the cancer types where CPNE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.052	0.567	<.001	36	view →
UCEC	OS	Median	All	1.000	0.665	.022	30	view →
HNSC	OS	Median	All	0.168	0.752	<.001	30	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: CPNE1 tumor-vs-normal RNA expression · all CPNE1 data types