CPN1

Across TCGA pan-cancer cohorts, CPN1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CPN1 data layer compared with 19 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CPN1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CPN1 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

HNSC, SKCM, and LIHC are the cancer types where CPN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.120	0.686	<.001	42	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	9	view →
LIHC	DFS	Median	All	0.153	0.555	.024	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	DFS	Median	II,III,IV	1.000	0.474	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CPN1–HNSC (DFS)

Open the HNSC breakdown →