CPN1

Across TCGA pan-cancer cohorts, CPN1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CPN1 data layer compared with 19 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CPN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CPN1 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

COAD, LUAD, and GBM are the cancer types where CPN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.885	1.000	.019	42	view →
LUAD	OS	Median	III,IV	0.285	0.879	.001	27	view →
GBM	DFS	Tertile	All	0.496	0.202	.016	10	view →
CCRCC	OS	Median	All	1.000	0.909	.019	10	view →
OV	DFS	Median	All	0.938	0.617	.021	8	view →
UCEC	DFS	Quartile	All	0.839	0.983	.017	8	view →
PDAC	OS	Median	III,IV	0.318	0.562	.012	6	view →
LSCC	OS	Quartile	All	0.946	1.000	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CPN1–COAD (DFS)

Open the COAD breakdown →