CPN1

Across TCGA patient cohorts, CPN1 mutation is significantly associated with the RNA expression of many other genes, with 2,600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPN1-associated genes across cancer lineages are RNA5SP143, GIT1, and MRPS30. Each is linked with CPN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CPN1-to-partner and partner-to-CPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP143 grouped by CPN1-low versus CPN1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPN1→partner) and Y-score (partner→CPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP143 →	+0.113	+5.342	<.001	.001	3	3
STAD	GIT1 →	+0.657	+3.355	.002	.005	3	3
STAD	MRPS30 →	+0.457	+3.182	.008	.009	2	4
STAD	UBAC1 →	+0.595	+3.186	<.001	.009	3	3
STAD	SMPD4 →	+0.556	+3.355	.003	.005	3	3
STAD	ATP5F1A →	+0.575	+3.182	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,600 associations by consensus.

RNA5SP143 by CPN1 expression — LUAD

Explore this box plot interactively →