CPN1

Across TCGA patient cohorts, CPN1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPN1-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and JNK_pT183_Y185. Each is linked with CPN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CPN1-to-partner and partner-to-CPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CPN1-low versus CPN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPN1→partner) and Y-score (partner→CPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.338	+2.000	.036	.032	3	3
UCEC	Caspase-7-cleavedD198 →	+0.612	+2.189	.022	.034	3	3
UCEC	JNK_pT183_Y185 →	-0.183	-1.986	.016	.032	3	2
STAD	Shc_pY317 →	-0.204	-3.000	.024	.036	3	2
UCEC	JNK2 →	+0.214	+2.000	.016	.032	3	2
UCEC	MEK1 →	+0.432	+3.459	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eEF2 by CPN1 expression — UCEC

Explore this box plot interactively →