CPLX4

Across TCGA cell cohorts, CPLX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 855 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CPLX4-associated GO terms across cancer lineages are Regulation of proteasomal protein catabolic process, Protein localization to endoplasmic reticulum, and COPII-coated vesicle cargo loading. Each is linked with CPLX4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CPLX4-to-partner and partner-to-CPLX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteasomal protein catabolic process grouped by CPLX4-low versus CPLX4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CPLX4→partner) and Y-score (partner→CPLX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of proteasomal protein catabolic process →	+0.039	+0.031	<.001	<.001	3	5
PANCREAS	Protein localization to endoplasmic reticulum →	+0.131	+0.036	<.001	.006	3	5
SOFT_TISSUE	COPII-coated vesicle cargo loading →	+0.062	+0.027	.001	.001	3	5
BLOOD_Leukemia	Maintenance of protein localization in endoplasmic reticulum →	+0.108	+0.011	.002	.005	3	5
SOFT_TISSUE	Regulation of protein modification by small protein conjugation or removal →	+0.039	+0.018	<.001	.003	3	5
SOFT_TISSUE	Regulation of protein ubiquitination →	+0.031	+0.017	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 855 associations by consensus.

Regulation of proteasomal protein catabolic process by CPLX4 expression — SOFT_TISSUE

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