CPLX4

Across TCGA cell cohorts, CPLX4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPLX4-associated genes across cancer lineages are NPHS2, MSGN1, and C12orf40. Each is linked with CPLX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPLX4-to-partner and partner-to-CPLX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by CPLX4-low versus CPLX4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPLX4→partner) and Y-score (partner→CPLX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPHS2 →	+0.082	+4.029	.003	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.115	+5.345	<.001	<.001	3	1
LARGE_INTESTINE	C12orf40 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.336	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	KRTAP10-3 →	+0.045	+3.920	<.001	.005	3	1
LARGE_INTESTINE	RBMY1J →	+0.008	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

NPHS2 by CPLX4 expression — LARGE_INTESTINE

Explore this box plot interactively →