CPLX2

Across TCGA patient cohorts, CPLX2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPLX2-associated genes across cancer lineages are PDCD4, Cyclin-D1, and A-Raf_pS299. Each is linked with CPLX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPLX2-to-partner and partner-to-CPLX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CPLX2-low versus CPLX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPLX2→partner) and Y-score (partner→CPLX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.701	-3.575	<.001	.002	3	2
UCEC	Cyclin-D1 →	+0.164	+2.321	.016	.034	3	2
UCEC	A-Raf_pS299 →	-0.117	-3.169	.020	.019	3	1
UCEC	ERK2 →	+0.232	+1.700	.004	.044	3	1
UCEC	FoxM1 →	+0.281	+2.222	.010	.011	3	1
UCEC	GAPDH →	+0.529	+1.700	.020	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PDCD4 by CPLX2 expression — UCEC

Explore this box plot interactively →