CPLX1

Across TCGA cell cohorts, CPLX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,322 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CPLX1-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Substrate adhesion-dependent cell spreading, and Regulation of phospholipid efflux. Each is linked with CPLX1 in more than 11 cancer types. Because this analysis shows association rather than direction, both CPLX1-to-partner and partner-to-CPLX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by CPLX1-low versus CPLX1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CPLX1→partner) and Y-score (partner→CPLX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Transcription pausing by RNA polymerase II →	+0.103	+1.840	.002	.002	3	12
OVARY	Substrate adhesion-dependent cell spreading →	-0.118	-0.632	<.001	.004	2	11
SOFT_TISSUE	Regulation of phospholipid efflux →	+0.847	+0.793	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of phospholipid efflux →	+0.847	+0.793	<.001	<.001	3	10
OVARY	Establishment of epithelial cell apical/basal polarity →	-0.134	-0.703	<.001	.005	2	10
LUNG_SCLC	Exocytic process →	+0.077	+2.132	.003	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,322 associations by consensus.

Transcription pausing by RNA polymerase II by CPLX1 expression — LUNG_SCLC

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