CPLANE2

Across TCGA patient cohorts, CPLANE2 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPLANE2-associated genes across cancer lineages are HSBP1P2, OR52W1, and OR2B7P. Each is linked with CPLANE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPLANE2-to-partner and partner-to-CPLANE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSBP1P2 grouped by CPLANE2-low versus CPLANE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPLANE2→partner) and Y-score (partner→CPLANE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSBP1P2 →	+0.669	+3.541	.002	.007	3	2
SKCM	OR52W1 →	+0.058	+3.894	.008	.008	3	1
SKCM	OR2B7P →	+0.073	+4.199	.003	.004	3	1
SKCM	DEFB109B →	+0.127	+5.634	<.001	.001	3	1
SKCM	MIR181B2 →	+0.893	+3.913	<.001	.007	3	1
SKCM	MIR921 →	+0.589	+4.744	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

HSBP1P2 by CPLANE2 expression — UCEC

Explore this box plot interactively →