CPLANE2

Across TCGA cell cohorts, CPLANE2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPLANE2-associated genes across cancer lineages are IL2, ESX1, and ZNF831. Each is linked with CPLANE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPLANE2-to-partner and partner-to-CPLANE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by CPLANE2-low versus CPLANE2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPLANE2→partner) and Y-score (partner→CPLANE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IL2 →	+0.060	+5.022	<.001	.002	3	1
LARGE_INTESTINE	ESX1 →	+0.022	+4.467	.001	.004	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

IL2 by CPLANE2 expression — LARGE_INTESTINE

Explore this box plot interactively →