CPEB2-DT

Across TCGA pan-cancer cohorts, CPEB2-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CPEB2-DT data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CPEB2-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CPEB2-DT expression acts as an unfavorable survival marker, although some lineages such as PAAD and HNSC show a favorable association.

UVM, PAAD, and BLCA are the cancer types where CPEB2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.333	0.940	.002	50	view →
PAAD	OS	Tertile	All	0.523	0.225	.008	37	view →
BLCA	OS	Tertile	IV	0.150	0.443	<.001	27	view →
HNSC	DFS	Quartile	II,III,IV	0.712	0.548	.017	25	view →
ACC	OS	Median	IV	0.898	0.483	.013	21	view →
LGG	OS	Quartile	All	0.794	0.926	.006	19	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	18	view →
KIRP	DFS	Quartile	All	1.000	0.573	.007	16	view →
TGCT	DFS	Quartile	II,III,IV	0.587	1.000	.027	12	view →
LUAD	DFS	Tertile	IV	0.373	0.677	.038	12	view →
SKCM	OS	Median	IV	0.827	0.321	.006	12	view →
CHOL	DFS	Tertile	III,IV	0.095	0.751	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CPEB2-DT–UVM (DFS)

Open the UVM breakdown →