Across TCGA pan-cancer cohorts, CPEB1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CPEB1’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CPEB1 RNA is repressed in tumor relative to normal tissue. In most cancer types CPEB1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.
BLCA, COAD, and KIRP are the cancer types where CPEB1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPEB1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.