CPD

Across TCGA patient cohorts, CPD mutation is significantly associated with the RNA expression of many other genes, with 4,949 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPD-associated genes across cancer lineages are THYN1, BRPF1, and RECQL4. Each is linked with CPD in more than 2 cancer types. Because this analysis shows association rather than direction, both CPD-to-partner and partner-to-CPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THYN1 grouped by CPD-low versus CPD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPD→partner) and Y-score (partner→CPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THYN1 →	+0.341	+3.828	.003	<.001	3	3
UCEC	BRPF1 →	+0.424	+1.968	<.001	<.001	3	3
UCEC	RECQL4 →	+0.529	+3.807	.002	<.001	3	3
UCEC	GHITM →	+0.486	+1.947	.001	<.001	3	3
UCEC	RPUSD2 →	+0.375	+4.129	<.001	<.001	3	3
UCEC	HIF1AN →	+0.292	+2.850	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,949 associations by consensus.

THYN1 by CPD expression — UCEC

Explore this box plot interactively →