CPD

Across TCGA patient cohorts, CPD mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPD-associated genes across cancer lineages are TIGAR, ASNS, and ATM. Each is linked with CPD in more than 2 cancer types. Because this analysis shows association rather than direction, both CPD-to-partner and partner-to-CPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by CPD-low versus CPD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPD→partner) and Y-score (partner→CPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.107	+1.316	.028	.015	3	3
UCEC	ASNS →	+0.387	+1.584	<.001	.017	3	3
UCEC	ATM →	-0.452	-2.502	.001	.001	3	3
UCEC	eIF4E →	+0.171	+1.777	.011	.002	3	2
UCEC	JNK2 →	+0.190	+1.777	.002	.002	3	2
UCEC	mTOR_pS2448 →	-0.104	-1.571	.029	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

TIGAR by CPD expression — UCEC

Explore this box plot interactively →