CPD

Across TCGA cell cohorts, CPD mutation is significantly associated with the RNA expression of many other genes, with 836 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPD-associated genes across cancer lineages are PRAMEF20, SLC10A2, and PROP1. Each is linked with CPD in more than 1 cancer types. Because this analysis shows association rather than direction, both CPD-to-partner and partner-to-CPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by CPD-low versus CPD-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPD→partner) and Y-score (partner→CPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRAMEF20 →	+0.013	+4.906	<.001	.006	3	2
OESOPHAGUS	SLC10A2 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	PROP1 →	+0.030	+4.906	<.001	.006	3	1
OESOPHAGUS	ZNF99 →	+0.023	+4.906	<.001	.006	3	1
SKIN	CSN2 →	+0.091	+4.415	<.001	.007	3	1
BLOOD_Leukemia	SLC6A17 →	+0.150	+3.359	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 836 associations by consensus.

PRAMEF20 by CPD expression — OESOPHAGUS

Explore this box plot interactively →