CPB2

Across TCGA patient cohorts, CPB2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPB2-associated genes across cancer lineages are Notch1, Annexin-1, and TFRC. Each is linked with CPB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPB2-to-partner and partner-to-CPB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CPB2-low versus CPB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPB2→partner) and Y-score (partner→CPB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.158	+2.247	.002	.001	3	2
UCEC	Annexin-1 →	+0.697	+2.604	<.001	.005	3	2
UCEC	TFRC →	+0.528	+3.321	.006	.009	3	2
UCEC	YB-1 →	+0.125	+2.222	.032	.010	3	2
UCEC	Bap1-c-4 →	+0.160	+2.242	.046	.005	3	2
UCEC	C-Raf →	+0.110	+1.847	.036	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Notch1 by CPB2 expression — UCEC

Explore this box plot interactively →