CPB1

Across TCGA patient cohorts, CPB1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPB1-associated genes across cancer lineages are Cyclin-B1, FoxM1, and Bap1-c-4. Each is linked with CPB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPB1-to-partner and partner-to-CPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CPB1-low versus CPB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPB1→partner) and Y-score (partner→CPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.659	+2.807	.001	.003	3	2
UCEC	FoxM1 →	+0.203	+1.847	.033	.008	3	2
SKCM	Bap1-c-4 →	+0.350	+3.000	.043	.036	3	1
UCEC	Mre11 →	-0.062	-3.295	.047	.009	3	1
UCEC	p27_pT198 →	+0.088	+1.502	.025	.030	3	1
UCEC	PEA-15_pS116 →	-0.254	-1.874	.048	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Cyclin-B1 by CPB1 expression — UCEC

Explore this box plot interactively →