CPA5

Across TCGA patient cohorts, CPA5 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPA5-associated genes across cancer lineages are Stathmin, 4E-BP1, and EGFR_pY1068. Each is linked with CPA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CPA5-to-partner and partner-to-CPA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by CPA5-low versus CPA5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPA5→partner) and Y-score (partner→CPA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Stathmin →	+0.194	+2.178	.007	.035	3	2
UCEC	4E-BP1 →	+0.345	+3.199	.002	.009	2	3
UCEC	EGFR_pY1068 →	-0.303	-3.584	.004	.002	3	2
UCEC	C-Raf →	+0.160	+2.000	.008	.030	3	2
UCEC	Di-Ras3 →	-0.191	-2.906	.002	.001	3	2
COAD	eIF4E →	+0.247	+2.820	.003	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Stathmin by CPA5 expression — COAD

Explore this box plot interactively →