CPA4

Across TCGA pan-cancer cohorts, CPA4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CPA4 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CPA4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CPA4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where CPA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.826	0.588	.040	2	view →
PDAC	OS	Median	III,IV	0.240	0.710	.047	2	view →
CCRCC	OS	Median	II,III,IV	0.570	0.894	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CPA4–HNSC (DFS)

Open the HNSC breakdown →