CPA3

Across TCGA cell cohorts, CPA3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CPA3-associated genes across cancer lineages are MAGEB5, PIRT, and RNASE9. Each is linked with CPA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPA3-to-partner and partner-to-CPA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by CPA3-low versus CPA3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPA3→partner) and Y-score (partner→CPA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PIRT →	+0.006	+4.643	<.001	.008	3	1
LUNG_SCLC	RNASE9 →	+0.029	+5.029	<.001	.006	3	1
BLOOD_Leukemia	OPN1LW →	+0.044	+4.539	<.001	.007	3	1
BLOOD_Leukemia	PAX4 →	+0.025	+4.276	<.001	.007	3	1
BLOOD_Leukemia	CFHR5 →	+0.004	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MAGEB5 by CPA3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →