CP

Across TCGA pan-cancer cohorts, CP mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CP data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and OV show a favorable association.

COAD, LUAD, and UCEC are the cancer types where CP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	66	view →
LUAD	DFS	Median	III,IV	0.247	0.805	.001	54	view →
UCEC	DFS	Median	II,III,IV	0.480	0.946	.003	16	view →
LSCC	DFS	Quartile	All	0.839	1.000	.007	12	view →
CCRCC	OS	Tertile	IV	1.000	0.216	.036	6	view →
OV	DFS	Median	All	1.000	0.684	.024	4	view →
HNSC	OS	Tertile	II,III,IV	0.943	1.000	.028	4	view →
GBM	OS	Quartile	All	0.714	0.943	.033	3	view →
PDAC	OS	Tertile	III,IV	0.304	0.615	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CP–COAD (DFS)

Open the COAD breakdown →