CP

Across TCGA patient cohorts, CP mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CP-associated genes across cancer lineages are ERK2, NDRG1_pT346, and p38-MAPK_pT180_Y182. Each is linked with CP in more than 1 cancer types. Because this analysis shows association rather than direction, both CP-to-partner and partner-to-CP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CP-low versus CP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CP→partner) and Y-score (partner→CP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERK2 →	+0.213	+1.891	.016	.027	3	2
SKCM	NDRG1_pT346 →	-0.794	-2.459	.004	.018	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.460	-1.794	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.359	-1.378	<.001	.008	3	2
UCEC	MEK1 →	+0.372	+2.321	<.001	<.001	3	2
UCEC	Notch1 →	+0.172	+1.817	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ERK2 by CP expression — SKCM

Explore this box plot interactively →