CP

Across TCGA cell cohorts, CP mutation is significantly associated with the RNA expression of many other genes, with 1,111 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CP-associated genes across cancer lineages are TSHB, FHL5, and IL3. Each is linked with CP in more than 1 cancer types. Because this analysis shows association rather than direction, both CP-to-partner and partner-to-CP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by CP-low versus CP-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CP→partner) and Y-score (partner→CP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TSHB →	+0.075	+4.832	<.001	.002	3	1
BREAST	FHL5 →	+0.075	+4.312	<.001	.001	3	1
BREAST	IL3 →	+0.014	+4.196	<.001	.006	3	1
BREAST	PPDPFL →	+0.076	+4.415	<.001	.001	3	1
SKIN	H2BW2 →	+0.132	+4.467	<.001	.004	3	1
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,111 associations by consensus.

TSHB by CP expression — CNS

Explore this box plot interactively →