COX7B2

Across TCGA cell cohorts, COX7B2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible COX7B2-associated genes across cancer lineages are HSFY2, KRTAP6-3, and KRTAP19-3. Each is linked with COX7B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX7B2-to-partner and partner-to-COX7B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by COX7B2-low versus COX7B2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX7B2→partner) and Y-score (partner→COX7B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LUNG_SCLC	KRTAP6-3 →	+0.174	+5.029	<.001	.006	3	1
LUNG_SCLC	KRTAP19-3 →	+0.347	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	GPR101 →	+0.012	+4.887	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

HSFY2 by COX7B2 expression — LARGE_INTESTINE

Explore this box plot interactively →