COX7B

Across TCGA patient cohorts, COX7B mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX7B-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and Ku80. Each is linked with COX7B in more than 1 cancer types. Because this analysis shows association rather than direction, both COX7B-to-partner and partner-to-COX7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by COX7B-low versus COX7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX7B→partner) and Y-score (partner→COX7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.283	+2.817	.023	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.178	-2.312	.003	.034	3	1
UCEC	Ku80 →	+0.305	+2.820	.007	.035	3	1
UCEC	mTOR_pS2448 →	-0.194	-2.459	.006	.020	3	1
UCEC	Notch1 →	+0.187	+2.820	.005	.035	3	1
UCEC	p27_pT198 →	+0.123	+2.459	.017	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FoxM1 by COX7B expression — UCEC

Explore this box plot interactively →