COX7A2

Across TCGA pan-cancer cohorts, COX7A2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated COX7A2 data layer compared with 28 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher COX7A2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COX7A2 expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

HNSC, COAD, and LUAD are the cancer types where COX7A2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.789	0.976	.004	45	view →
COAD	DFS	Median	II,III,IV	1.000	0.883	.023	24	view →
LUAD	DFS	Quartile	II,III,IV	0.748	0.989	.020	11	view →
GBM	DFS	Tertile	All	0.897	0.569	<.001	10	view →
OV	DFS	Quartile	All	0.923	0.438	.032	8	view →
LSCC	DFS	Tertile	III,IV	1.000	0.475	.037	4	view →
CCRCC	DFS	Tertile	All	0.892	0.627	.017	4	view →
PDAC	OS	Quartile	II,III,IV	0.538	0.277	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

COX7A2–HNSC (OS)

Open the HNSC breakdown →