Across TCGA pan-cancer cohorts, COX6CP3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of COX6CP3’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where COX6CP3 RNA is repressed in tumor relative to normal tissue. In most cancer types COX6CP3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA and LUSC are the cancer types where COX6CP3 tumor–normal differential expression is most reproducible.