Across TCGA pan-cancer cohorts, COX6CP18 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of COX6CP18’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where COX6CP18 RNA is repressed in tumor relative to normal tissue. In most cancer types COX6CP18 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC and COAD are the cancer types where COX6CP18 tumor–normal differential expression is most reproducible.