COX6C

Across TCGA pan-cancer cohorts, COX6C mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of COX6C’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where COX6C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types COX6C is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and LUAD are the cancer types where COX6C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX6C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−1.570	<.001	12	view →
HNSC	All	II,III,IV	−0.863	<.001	11	view →
LUAD	Female	II,III,IV	+0.651	<.001	9	view →
COAD	Female	All	−0.313	<.001	9	view →
LSCC	Male	All	+0.540	<.001	8	view →
PDAC	All	II,III,IV	+0.792	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

COX6C–CCRCC

Open the CCRCC breakdown →