COX6B2

Across TCGA cell cohorts, COX6B2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,502 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible COX6B2-associated GO terms across cancer lineages are Regulation of extracellular matrix disassembly, Regulation of intracellular protein transport, and Regulation of intrinsic apoptotic signaling pathway. Each is linked with COX6B2 in more than 9 cancer types. Because this analysis shows association rather than direction, both COX6B2-to-partner and partner-to-COX6B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of extracellular matrix disassembly grouped by COX6B2-low versus COX6B2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COX6B2→partner) and Y-score (partner→COX6B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of extracellular matrix disassembly →	+0.219	+1.764	<.001	.001	3	10
BREAST	Regulation of intracellular protein transport →	+0.068	+1.376	.001	.003	3	10
URINARY_TRACT	Regulation of intrinsic apoptotic signaling pathway →	+0.070	+2.003	<.001	<.001	3	9
STOMACH	Cellular response to oxidative stress →	+0.054	+1.321	.001	.005	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell adhesion →	+0.068	+1.457	.002	.001	3	9
BREAST	Regulation of myoblast fusion →	+0.083	+1.810	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,502 associations by consensus.

Regulation of extracellular matrix disassembly by COX6B2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →