Across TCGA pan-cancer cohorts, COX6B1P6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of COX6B1P6’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where COX6B1P6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COX6B1P6 is over-expressed in tumor.
BRCA and LUAD are the cancer types where COX6B1P6 tumor–normal differential expression is most reproducible.