Across TCGA pan-cancer cohorts, COX6B1P3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of COX6B1P3’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where COX6B1P3 RNA is repressed in tumor relative to normal tissue. In most cancer types COX6B1P3 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
ESCA are the cancer types where COX6B1P3 tumor–normal differential expression is most reproducible.