COX6B1

Across TCGA pan-cancer cohorts, COX6B1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COX6B1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COX6B1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated COX6B1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where COX6B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.475	0.270	.001	41	view →
HNSC	DFS	Tertile	II,III,IV	0.900	1.000	.005	18	view →
LSCC	DFS	Median	II,III,IV	0.820	0.534	.015	11	view →
OV	DFS	Tertile	All	1.000	0.535	.045	8	view →
UCEC	DFS	Quartile	III,IV	1.000	0.417	.040	8	view →
GBM	DFS	Median	All	0.865	0.629	.004	5	view →
CCRCC	DFS	Quartile	III,IV	0.222	0.887	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COX6B1–PDAC (OS)

Open the PDAC breakdown →