COX6B1

Across TCGA patient cohorts, COX6B1 mutation is significantly associated with the RNA expression of many other genes, with 115 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible COX6B1-associated genes across cancer lineages are RN7SL228P, MRPL9P1, and MGAT2P1. Each is linked with COX6B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX6B1-to-partner and partner-to-COX6B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL228P grouped by COX6B1-low versus COX6B1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX6B1→partner) and Y-score (partner→COX6B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL228P →	+0.150	+5.309	.001	.003	3	2
LUSC	MRPL9P1 →	+0.275	+4.532	<.001	.005	3	2
SKCM	MGAT2P1 →	+0.211	+5.362	.007	.005	3	2
UCEC	RNU6-206P →	+0.313	+5.245	<.001	.002	3	2
UCEC	NUTF2P8 →	+0.155	+3.982	.001	.003	3	1
SKCM	OR51M1 →	+0.081	+5.224	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

RN7SL228P by COX6B1 expression — LUSC

Explore this box plot interactively →