COX6A2

Across TCGA pan-cancer cohorts, COX6A2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COX6A2 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COX6A2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COX6A2 expression acts as an unfavorable survival marker.

COAD, LIHC, and UCEC are the cancer types where COX6A2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.208	0.802	<.001	30	view →
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

COX6A2–COAD (OS)

Open the COAD breakdown →