COX6A1

Across TCGA pan-cancer cohorts, COX6A1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COX6A1 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COX6A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COX6A1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

UCEC, LGG, and LIHC are the cancer types where COX6A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.080	0.593	.009	20	view →
LGG	OS	Median	All	0.182	0.909	<.001	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
SKCM	DFS	Median	All	0.058	0.757	<.001	12	view →
BLCA	OS	Median	III,IV	1.000	0.347	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COX6A1–UCEC (OS)

Open the UCEC breakdown →