COX6A1

Across TCGA patient cohorts, COX6A1 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible COX6A1-associated genes across cancer lineages are PPIAL4F, MIR4307, and CYP4F30P. Each is linked with COX6A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX6A1-to-partner and partner-to-COX6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4F grouped by COX6A1-low versus COX6A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX6A1→partner) and Y-score (partner→COX6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPIAL4F →	+0.076	+3.775	<.001	<.001	3	2
HNSC	MIR4307 →	+0.582	+7.954	<.001	.008	3	2
BLCA	CYP4F30P →	+0.074	+4.194	<.001	.002	3	2
HNSC	RBMY1HP →	+0.024	+7.954	<.001	.008	3	1
HNSC	MIR764 →	+0.578	+7.954	<.001	.008	3	1
SKCM	DEFB108D →	+0.114	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

PPIAL4F by COX6A1 expression — UCEC

Explore this box plot interactively →