COX5BP6

Across TCGA pan-cancer cohorts, COX5BP6 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of COX5BP6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COX5BP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COX5BP6 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, BLCA, and KICH are the cancer types where COX5BP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX5BP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.300	<.001	8	view →
BLCA	All	III,IV	+0.997	.006	6	view →
KICH	All	All	−0.590	<.001	6	view →
CHOL	All	All	+1.646	<.001	5	view →
STAD	Male	II,III,IV	+0.915	<.001	5	view →
LUSC	All	All	+0.456	.001	5	view →
READ	All	III,IV	+1.539	.009	4	view →
THCA	Male	III,IV	−0.615	.012	4	view →
LUAD	Female	All	+0.719	<.001	3	view →
LIHC	All	All	+0.302	.004	3	view →
PAAD	Female	All	+1.005	.040	2	view →
PRAD	All	All	+0.909	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

COX5BP6–COAD

Open the COAD breakdown →