COX5A

Across TCGA pan-cancer cohorts, COX5A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COX5A data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher COX5A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COX5A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where COX5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.970	0.504	.002	20	view →
LSCC	DFS	Tertile	II,III,IV	0.948	0.587	.009	16	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	15	view →
HNSC	OS	Tertile	II,III,IV	0.926	1.000	.014	4	view →
GBM	OS	Median	All	0.888	0.742	.015	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COX5A–CCRCC (DFS)

Open the CCRCC breakdown →