COX4I1

Across TCGA pan-cancer cohorts, COX4I1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COX4I1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COX4I1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COX4I1 expression acts as an unfavorable survival marker, although some lineages such as COAD and OV show a favorable association.

COAD, OV, and GBM are the cancer types where COX4I1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	1.000	0.884	.034	24	view →
OV	DFS	Tertile	All	0.876	0.517	.032	8	view →
GBM	DFS	Median	All	0.812	0.626	.006	6	view →
CCRCC	DFS	Median	III,IV	0.718	0.451	.024	6	view →
LSCC	OS	Median	II,III,IV	1.000	0.878	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COX4I1–COAD (DFS)

Open the COAD breakdown →