COX4I1

Across TCGA patient cohorts, COX4I1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,229 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COX4I1-associated genes across cancer lineages are KIRREL1, VIM, and SYDE1. Each is linked with COX4I1 in more than 6 cancer types. Because this analysis shows association rather than direction, both COX4I1-to-partner and partner-to-COX4I1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COX4I1 versus KIRREL1 in BRCA, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX4I1→partner) and Y-score (partner→COX4I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIRREL1 →	-1.161	-0.501	<.001	<.001	3	7
BRCA	VIM →	-1.096	-0.404	<.001	<.001	3	7
OV	SYDE1 →	-0.730	-0.284	.003	.006	3	6
COAD	KDELR3 →	-0.720	-0.259	.001	.002	3	5
OV	ZNF423 →	-1.562	-0.445	<.001	<.001	3	5
UCEC	OLFM2 →	-1.187	-0.564	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,229 associations by consensus.

COX4I1 vs KIRREL1 — BRCA

Explore this scatter interactively →