COX4I1

Across TCGA patient cohorts, COX4I1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX4I1-associated genes across cancer lineages are ETS-1, FASN, and p90 RSK. Each is linked with COX4I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX4I1-to-partner and partner-to-COX4I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETS-1 grouped by COX4I1-low versus COX4I1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX4I1→partner) and Y-score (partner→COX4I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ETS-1 →	-0.372	-3.000	.025	.036	3	1
UCEC	FASN →	+0.472	+3.321	.022	.010	3	1
UCEC	p90 RSK →	+0.198	+3.009	.049	.019	3	1
UCEC	Src →	+0.263	+3.321	.014	.010	3	1
UCEC	Caveolin-1 →	-0.934	-3.000	.014	.036	3	1
UCEC	c-Met_pY1235 →	+0.104	+3.331	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ETS-1 by COX4I1 expression — UCEC

Explore this box plot interactively →