Across TCGA pan-cancer cohorts, COX20 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of COX20’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COX20 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types COX20 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where COX20 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX20 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.352	<.001	9	view →
LUAD	Male	II,III,IV	+0.459	<.001	8	view →
LSCC	Male	III,IV	+0.458	<.001	8	view →
CCRCC	Male	All	−0.279	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: COX20 RNA expression & survival · all COX20 data types