COX18

Across TCGA cell cohorts, COX18 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COX18-associated genes across cancer lineages are GPR6, MSGN1, and TAFA1. Each is linked with COX18 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX18-to-partner and partner-to-COX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR6 grouped by COX18-low versus COX18-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX18→partner) and Y-score (partner→COX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR6 →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.278	+3.688	<.001	.002	3	1
LARGE_INTESTINE	CELA3B →	+0.221	+3.592	<.001	.006	3	1
BREAST	CCDC105 →	+0.006	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	LGALS16 →	+0.057	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GPR6 by COX18 expression — LARGE_INTESTINE

Explore this box plot interactively →