COX17

Across TCGA pan-cancer cohorts, COX17 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated COX17 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COX17 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COX17 expression acts as an unfavorable survival marker, although some lineages such as MESO and DLBC show a favorable association.

COAD, KICH, and HNSC are the cancer types where COX17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.593	0.788	<.001	61	view →
KICH	DFS	Tertile	III,IV	0.336	1.000	.006	52	view →
HNSC	DFS	Quartile	All	0.499	0.662	.001	48	view →
LGG	DFS	Tertile	All	0.628	0.808	<.001	31	view →
GBM	OS	Tertile	All	0.247	0.414	<.001	31	view →
MESO	DFS	Median	II,III,IV	0.505	0.296	.005	25	view →
DLBC	DFS	Tertile	All	1.000	0.404	.018	24	view →
KIRP	DFS	Tertile	III,IV	0.221	0.841	.007	23	view →
SKCM	OS	Quartile	All	0.475	0.238	<.001	18	view →
ESCA	DFS	Tertile	All	0.283	0.517	.006	18	view →
PRAD	DFS	Median	All	0.684	0.888	<.001	18	view →
BRCA	OS	Tertile	All	0.945	0.979	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

COX17–COAD (DFS)

Open the COAD breakdown →