COX16

Across TCGA pan-cancer cohorts, COX16 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated COX16 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher COX16 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COX16 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC and CCRCC are the cancer types where COX16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.248	0.750	.016	10	view →
CCRCC	OS	Median	III,IV	0.985	0.104	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

COX16–HNSC (DFS)

Open the HNSC breakdown →